Iziphumo Ezisixhenxe zeAntithrombotic ziye zasetyenziswa Umfanekiso obonakalayo

Kwasetyenziswa iziphumo ezisixhenxe zeAntithrombotic

Inkcazelo emfutshane:

Kukho iindidi ezimbini zeeproteni kubuhlungu benyoka, enye yazo ithe tye.I-enzyme enyibilikisa i-fibrin (protolysin) ibizwa ngokuba yi-fibrin (protolysin) enzyme (Ifutshane kwi-plasminase,fi b ri no L yt I cenz YM E, FLE).Ukongeza kwi-fibrin ehlazisayo kunye ne-fibrinogen, Akukho kusebenze kwe-plasminogen emzimbeni womntu, akukho hydrolysis yezinye izinto ezidibeneyo kunye ne-platelet membrane, inomphumela ocacileyo we-antithrombotic.Enye kukucinezela iProthrombin yenziwe yasebenza ukulibazisa inkqubo yokudibanisa kwaye ayinawo umsebenzi we-enzyme.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Le enzyme yaveliswa okokuqala yi-ATODA njl.njl kwi-Japan yellow-green iron head snake venom
I-anticoagulant mechanism ye-anticoagulant protein yaxoxwa.
Oku kuboniswa ngokusebenzisana ne-clotting factor IX okanye i-clotting factor X kwi-calcium ions
Ukuqulunqwa kwe-1: I-1 eyinkimbinkimbi ukuphumeza ixesha elide lokuxhamla;Kamva,
LU et al.Agk I strodona CU
I-ACFI, i-anticoagulant factor, yayibekwe yodwa kwityhefu yenyoka.ULiu Qing
ULiang et al.wafunda i-anticoagulant factor kwaye wafumanisa ukuba i-AC FI ine-calcium ion
Kwaye umsebenzi wayo we-anticoagulant kunye nesakhiwo sendawo sasihambelana ne-calcium ions.
Emva koko, uXu Xiaolong et al.yahlula ityhefu ye-agkistrodon halys ngendlela ephuculweyo yokwahlula
Enye i-anticoagulant factor, i-ACFI I, kunye ne-anticoagulant yale nto ye-anticoagulant
Uphando lokuphunyezwa komatshini, lufumene ukuba kufana ne-AC FI, luhlobo lwesibini.hayi
Ning et al.yahlula into entsha ye-anticoagulant kwityhefu ye-agkistrodon agkistrodon
Kwafunyaniswa ukuba akukho msebenzi we-fibrinolytic kunye ne-phospholipase A
Umsebenzi kunye nomsebenzi wokopha.UQian Xiaojiang et al waseHunan wavelisa amanqaku etyhefu ye-agkistrodon
Amacandelo asebenzayo e-Fibrinolytic abekwe yedwa kwaye aqinisekiswa yi-thrombolytic assay in vitro
Inomphumela ocacileyo we-thrombolytic.Ubunyulu bohlulwa ngeendlela ezintathu zechromatographic
Kwaye umsebenzi we-enzyme uphuculwe kakhulu.Ngenxa yokuba inxalenye ye-plasminase iqulethe
Inxalenye yokopha kunzima ukuhlukana kwaye ixabiso layo lesicelo seklinikhi alibonakali.Li Zhaoyan njl.
Ngokusebenzisa iinzame zokufumana i-enzyme ye-fibrinolytic ngaphandle kwamacandelo okopha, impendulo yeklinikhi ye-fibrinolytic enzyme
Ngenkxaso yobugcisa.Zhou Xianli [18] wabonakalisa ngokusebenzisa imifuniselo ukuba
Zombini i-thrombin kunye ne-fibrinolytic enzyme ye-agkistrodon halys venom inesiphumo esicacileyo se-thrombolytic, kodwa
Isiphumo esithe ngqo se-fibrinolytic enzyme sinamandla kune-thrombin.
Ke i-thrombin yi-thrombolytic ecothayo, ukuvuselelwa okuqhubekayo kwemithambo yegazi,
Ukuphucula ukunyamezela kwemithambo yegazi kwindawo ye-ischemic, ugweme ukuchithwa kwegazi okubangelwa ukuphuka kwe-vascular
I-Cleft, inefuthe elingcono kwinqanaba lokuqala le-thrombosis, ukusetyenziswa okubini okudibeneyo