Inzululwazi isebenzisa i-microscope kwilebhu

imveliso

Ubuhlungu beNyoka obuvela kwi-Agkistrodon (iNyoka enamanyathelo amahlanu) kufuneka inyangwe ngeSerum yeAntihematic

Inkcazelo emfutshane:

Izilingo ezimbini zeklinikhi zenziwa, uvavanyo olulawulwa yi-placebo olungahleliwe kunye nolingo olulungileyo olulawulwa ngokungahleliwe.Onke amanxeba ayesopha ngenxa yokusikwa kodonga lwesisu kutyando lwesisu.Izalathisi eziphambili zonyango zazinokulahleka kwegazi, ixesha le-hemostasis kunye nokulahleka kwegazi kwindawo nganye yeyunithi.I-placebo ehleliweyo kwiimvavanyo zeklinikhi kwiimeko ze-180 zabantu: umlinganiselo wamanqaku alinganayo alinganayo kwi-placebo, i-2 u kunye ne-3 u amaqela amathathu, i-preoperative 15-20 imizuzu ye-dosing enye ye-intravenous, iziphumo zibonisa ukuba le milinganiselo emibini ekopha, ixesha lokuphuma kwegazi kunye ukulahleka kwegazi kwi-unit area index yayiphezulu kune-placebo, kodwa akukho budlelwane boxinaniso-impendulo phakathi kwamaqela amabini.Kulingo lolawulo olulungileyo, bekukho izigulane ezingama-324 kwiqela lovavanyo kunye nezigulane ze-108 kwiqela lolawulo, kwaye idosi enye ye-2U yanikwa kwiqela lokulinga i-15-20 imizuzu ngaphambi kotyando ngenaliti enye ye-intravenous.Akukho ziziphumo zibi zibonwe kolu vavanyo lungentla.


Iinkcukacha zeMveliso

Iithegi zeMveliso

Uphononongo lubonise ukuba ezi nyoka zinobuhlungu ikakhulu zivelisa ityhefu ejikeleza igazi kunye ne-neurotoxins, enokubangela i-diffuse intravascular coagulation (DIC) kunye nokopha okulandelayo, ukothuka kunye nokusilela kwamalungu amaninzi.Ngokusekwe kuphononongo olucwangcisiweyo lwe-toxicology yegazi ye-snake venom kumazantsi e-Anhui, i-DIC yafunyanwa njengenye yeempawu zemvelo zezigulane zokulimala kwenyoka kunye netyhefu yokuqala, eyayahluke kwintetho yendabuko ye-DIC.Ngoko ke, ingcamango ye-"DIC efana" ye-syndrome kwizigulane ezilunywa yinyoka yacetywa okokuqala e-China (1988).Kwafunyaniswa ukuba i-TLE kunye ne-FE zezona zizathu ziphambili zale "DIC efana" (1992).Oku kubaluleke kakhulu ukucacisa iimpawu zokutshintsha kwegazi kwizigulane ezine-5-step snake venom, kwaye zibonelela ngesiseko sethiyori sokusetyenziswa kwe-antivenin ethile ukunyanga le ngxaki.

Kuphando kwindlela yokopha okubangelwa yityhefu yenyoka enamanyathelo amahlanu, kwafunyaniswa ukuba le tyhefu yenyoka inefuthe kumacandelo amathathu enkqubo ye-hemostatic yomzimba (izinto ezidityanisiweyo, iiplatelets kunye nodonga lwemithambo yegazi), phakathi kwazo ukopha. i-toxin ichaphazela ngokuthe ngqo ukufikeleleka kwee-capillaries.Ngelo xesha, kwafunyaniswa ukuba ukopha okukhulu kunye nokuvuvukala kwamalungu awonzakeleyo kwakungelula ukucombulula, okwakunxulumene nokuthintela ukunikezelwa kwegazi kwi-thoracic duct lymphatic coagulation factor kunye nesantya esibi se-lymphatic flow.Kwintsebenziswano yexesha elide kunye ne-Qimen Snakebite Institute, ezi ziphumo zophando ezisisiseko kunye nezisetyenzisiweyo ziye zadlala indima ebalulekileyo ekuqulunqeni isicwangciso sonyango lwe-snakebite ngokufanelekileyo kunye nokuqinisekisa ukhuseleko lwezigulane zenyoka, kwaye zifezekise iziphumo ezibalulekileyo zentlalo.Uphando oluphunyeziweyo luphumelele iMbasa yeMpumelelo yeNzululwazi neTekhnoloji yePhondo lase-Anhui, iMbasa yeNkqubela yeNzululwazi neTekhnoloji yePhondo lase-Anhui (1993), iSebe lezeMpilo (A) iBanga leNzululwazi kunye neMbasa yeQela lokuPhumelela kweTekhnoloji (1991);Ngo-1989, inkampani yasebenzisana ne-Wuhan Institute of Biological Products ukuphuhlisa i-antibody ye-monoclonal ngokuchasene ne-penta snake venom thrombin, eyayiyimpumelelo yokuqala e-China.Kwi-1996, inkampani yavelisa ngokudibeneyo kwaye yavelisa iimveliso ze-thrombin kunye ne-Institute of Biological Products and Drugs of Jinan Military Command (Yuwei Drug Approval No. 118004, Patent CN1141951A).


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