Ukusetyenziswa kwenaliti yesihlungu senyoka ye-hemagglutinin Umfanekiso obonakalayo

Ukusetyenziswa kwenaliti ye-snake venom hemagglutinin

Inkcazelo emfutshane:

I-Snake venom hemagglutinin, equlethe i-thrombin kunye ne-thrombin, isetyenziswe ngokubanzi kwikliniki ye-hemostasis kwiminyaka elishumi yakutshanje.I-Thrombin inokukhuthaza ukuhlanganiswa kweplatelet kwindawo yokopha, ikhuthaze ukuthotywa kwe-fibrinogen, ivelise i-fibrin monomer, kwaye emva koko i-polymerize ibe yi-fibrin e-insoluble, ikhuthaze i-thrombosis kwindawo yokopha;I-Thrombin yenza iprothrombin isebenze kwaye ikhawulezise ukuveliswa kwe-thrombin, ngaloo ndlela iququzelela inkqubo yokuqhawula.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

I-analgesia

I-enzyme ye-clotting yeklasi ye-Snake inetyhefu ephantsi, isebenze ngokukhawuleza (imizuzu emi-5 ~ 30 emva kokuba unyango lunokuvelisa umphumo we-hemostatic), ukusebenza kakuhle ixesha elide (emva kwesiphumo somsebenzi esizinzileyo kwiiyure ezingama-48 ~ 72) njl, kwaye zisetyenziswa ngokubanzi kwiimfuno zeklinikhi. ukunciphisa ukopha okanye iimeko ukopha (ezifana utyando, iyeza langaphakathi, obstetrics kunye gynecology, ophthalmology, otolaryngology, umlomo womngxunya ukopha kunye nezifo hemorrhagic), Ingasetyenziselwa ukuthintela ukopha (umzekelo, amayeza phambi kotyando unokuphepha okanye ukunciphisa ukopha. kwindawo yotyando nasemva kotyando).Ngokutsho kweengxelo zoncwadi, umlinganiselo osebenzayo we-snake venom hemagglutinin kwi-surgical incision hemostasis kunye ne-gastrointestinal ukopha ungcono kakhulu kune-phenolsulfonamides, i-sodium caroxesulfonate, i-vitamin K kunye namanye amachiza e-hemostatic.

Iinaliti zetyhefu yenyoka ye-hemagglutinin ebezithengiswa ngaphambili emarikeni ziquka inaliti ye-snake venom hemagglutinin (igama lorhwebo: Sulejuan), isitofu se-snake venom hemagglutinin injection (igama lorhwebo: Bangting), i-agkistrodon halys hemagglutinin injection (igama lorhwebo: Nangona kunjalo, akukho vavanyo lucwangcisiweyo olubonisa ukuba Umahluko obonakalayo ekusebenzeni kakuhle kwe-hemostatic kunye nezehlo zokusabela okungalunganga phakathi kweenyoka ezintathu.

I-Snake venom class clotting enzyme lulungiselelo lwebhayoloji, ukusuka kwisakhiwo sekhemikhali, yeyeprotheyini ye-heterologous, kunye neeseli zemast kwi-vivo okanye i-basophilic cell surface molecules, uthotho lweempendulo kwiseli, izinto ezisebenzayo ze-vascular, ezifana nokukhululwa kwe-histamine, izinto zokusabela okucothayo, uhlobo Ⅰ iziphumo zokwaliwa emzimbeni, zinokunxulunyaniswa ne-enzayimu iqulethe ukungcola.Ngelo xesha, zombini ukuxhatshazwa kokuhlinzwa kunye nentlungu emva kokuhlinzwa kunokukhokelela ekuphenduleni kwesigaba esibuhlungu (APR), njengokunyuka kobushushu bomzimba, ukunyuka kwe-glucose yegazi, ukunyuka kwe-catabolism, ibhalansi ye-nitrogen engafanelekanga kunye nokunyuka kwe-plasma ye-acute phase protein (APP) yoxinaniso.Ngeli xesha ukunika iprotein ye-allogen, umzimba uthambekele ekuchaseni, okanye nokuba kukwaliwa kakhulu.UZhao Shanshan et al.luhlalutye uncwadi kwiingxelo zetyala leempendulo ezimbi zenyoka enobuhlungu be-hemagglutinase naliti, kwaye yafumanisa ukuba i-57 ye-69 iimeko zokusabela okubi zenzeke kwiyure eli-1 emva kwesitofu, kwaye i-35 yazo yenzeke ngaphakathi kwe-1 ~ 5 imizuzu emva kwesitofu.I-acute-acute-alergic reaction, ukuba ifunyenwe ngexesha okanye ukuphathwa kakubi, ukuphuhliswa ngokukhawuleza kwesifo kunye nobungozi, kuya kubangela imiphumo emibi kwizigulane.

Ngoko ke, izibonakaliso kufuneka zilawulwe ngokungqongqo kusetyenziso lweklinikhi, kunye nembali yonyango yesigulane, imbali yeyeza, imbali ye-allergies kunye nembali yentsapho kufuneka ibuzwe ngononophelo ngaphambi kokusetyenziswa kokuqala.Lungiselela amayeza kunye namanqaku afunekayo kunyango olungxamisekileyo ngaphambi kokusetyenziswa.Isantya sokutofa kufuneka sicothe, kwaye iimpawu ezibalulekileyo zezigulane kunye nolunye utshintsho kufuneka lujongwe ngokusondeleyo ekuqaleni kweyeza.Emva kokuqwalaselwa ngenyameko imizuzu emininzi, izigulane zinokuhamba ukuze ziqinisekise ukuba akukho zithintelo zibi.