Ukusetyenziswa Kwetyhefu Yenyoka Ukuyeka ukopha kunye ne-Anticoagulation

Inkcazelo emfutshane:

Kwi-1981, i-defibrase ekhutshwe kwaye yaphuhliswa yi-Kunming Institute of Zoology, e-Yunnan, e-China, evela kwi-venom yenyoka ye-pentameter yaseShayina idlulise uvavanyo lobugcisa kwaye isetyenziswe kunyango lwe-333 iimeko ze-vascular thrombosis, kubandakanywa iimeko ze-242 ze-cerebral thrombosis, kunye. umlinganiselo osebenzayo wama-86.4%.I-agkistrodon agkistrodon acidase, ephuhliswe yi-China Medical University kunye ne-Shenyang Pharmaceutical College, isetyenziswe kunyango lwe-vascular occlusives eneziphumo ezanelisayo zeklinikhi.I-Snake venom Laboratory yaseChina Medical University iphuhlise i-snake venom antacid enzyme, enokunciphisa i-lipids yegazi, ivule imithambo yegazi, inciphise umxholo we-thrombin egazini, ikhulise i-prostacyclin, kwaye ikhulule izihlunu ezigudileyo zemithambo yegazi.Yinto efanelekileyo yokulungiselela i-anticoagulant thrombolytic.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

1. "i-defibrase" ekhutshwe kwaye iphuhliswe kwi-venom ye-pentapodes yaseTshayina yavunywa yi-Kunming Institute of Zoology, e-Yunnan, e-China ngo-1981. Yayisetyenziselwa unyango lwe-333 iimeko ze-vascular thrombosis, kubandakanywa iimeko ze-242 ze-cerebral thrombosis, kunye ne-thrombosis ye-cerebral thrombosis. umlinganiselo osebenzayo wama-86.4%.
2. I-Agkistrodon agkistrodon acidase, ephuhliswe ngokubambisana yi-China Medical University kunye ne-Shenyang Pharmaceutical College, iphumelele iziphumo zeklinikhi ezanelisayo kunyango lwe-vascular occlusives.
3. ILabhoratri yeNyoka yeNyoka yeYunivesithi yezoNyango yaseChina iphuhlise i-enzayimu ye-antacid yenyoka, enokunciphisa i-lipids yegazi, ivule imithambo yegazi, inciphise umxholo we-thrombin egazini, ikhulise i-prostacyclin, kwaye iphumle imisipha egudileyo yemithambo yegazi.Yinto efanelekileyo yokulungiselela i-anticoagulant thrombolytic.
4. Ityhefu yenyoka echasene namanyathelo amahlanu
I-Antivenomous snake serum luhlobo lweyeza, eliyimveliso yebhayoloji yokutofwa eyenziwe ngeplasma yehashe egonywe nge-agkistrodon (agkistrodon) itoxin, yokwetyiswa yi-enzayimi kwaye igalelwe ngaphandle.Iqulethe 2000U antivenomous snake serum.Olu hlobo lulungiswe ngokucolwa kwe-enzyme kunye nokugalelwa ityuwa kwiplasma yehashe egonywe ngetyhefu evela ku-A. agkistrodon.

5. Intsebenziswano kushishino-yunivesithi-uphando
I-Mashan Longshe Snake Industry Co., Ltd. ibambisene ne-snake Venom Institute ye-Guangxi Medical University ukubonelela ngetyhefu yenyoka ekumgangatho ophezulu ixesha elide, esetyenziselwa ukufunda i-biochemistry, i-molecular biology kunye ne-pharmacology ye-snake venom protein, kunye uchophele iiprojekthi ezingaphezu kwe-10 ezifana neSiseko seSizwe seSayensi yeNdalo kunye neeprojekthi zeSebe leNzululwazi nobuChwepheshe baseGuangxi.Iphumelele ibhaso lesibini le-Guangxi Science and Technology Progress Award kunye nebhaso lesithathu le-Guangxi Science and technology Progress Award.

6. Inyoka ye-hemagglutinin i-hemostatic agent ene-thrombin kinase-like effect, enokuguqulwa ibe yi-fibrin nge-hydrolyzing fibrinogen, ngaloo ndlela iphucula umsebenzi wokudibanisa umzimba;Le mveliso inomsebenzi wokuphucula ukuhlanganiswa kweplatelet, enokubangela ukuhlanganiswa okungaguqukiyo kweeplatelet, ngaloo ndlela kuphuculwe umsebenzi wokudibanisa, kodwa ayikhuthazi ukuhlanganiswa kweplatelet kwimithambo yegazi engaguqukiyo.
I-Hemocoagulation ye-agkistrodon agkistrodon njengoncedo lwe-hemostasis yenxeba elingaphezulu kuqhaqho.