[Abstract] Injongo Ukuphanda isiphumo sokuthintela iqhezu le-polypeptide encinci yemolekyuli (iqhezu le-K) ukusuka kwi-Agkistrodon acutus venom ekwandeni komhlaza we-ovarian cell line A2780 kunye nendlela yayo.Iindlela zokuvavanywa kwe-MTT zasetyenziselwa ukufumanisa inhibition yokukhula kwecandelo le-K kwimigca yeeseli zomhlaza;I-anti-cell adhesion effect yecandelo le-K yabonwa ngovavanyo lokubambelela;I-AO-EB i-double fluorescence staining kunye ne-flow cytometry yasetyenziselwa ukufumanisa ukwenzeka kwe-apoptosis.Iziphumo zecandelo le-K zithintele ukwanda kweseli yomhlaza wesibeleko somntu A2780 kwixesha-isiphumo kunye nobudlelwane bedosi, kwaye inokuxhathisa ukunamathela kweeseli kwi-FN.I-Apoptosis yabhaqwa yi-AO-EB i-double fluorescence staining kunye ne-flow cytometry.Ukuqukumbela Icandelo K linempembelelo enkulu yokuthintela ekwandeni komhlaza we-ovarian cell line A2780 in vitro, kwaye indlela yayo inokunxulumana ne-anti-cell adhesion and induction of apoptosis.
Ixesha lokuposa: Jan-11-2023