[Abstract] Injongo: Ukufunda isiphumo se-thrombin-like kunye ne-fibrinolytic enzymes ezibekwe zodwa kwaye zicocwe kwi-Agkistrodon acutus venom efanayo kwinkqubo yokudibanisa kwegazi.Iindlela: I-thrombin-like kunye ne-fibrinolytic enzymes zaye zahlukaniswa kwaye zahlanjululwa kwi-Agkistrodon acutus venom yi-DEAE-Sepharose CL-6B kunye ne-Sephadex G-75 chromatography, kwaye umphumo wazo zombini kwii-indexes ze-coagulation system indexes zabonwa nge-vivo experiments.Iziphumo: Inxalenye enye ye-thrombin-like kunye ne-fibrinolytic enzymes yahlukaniswa kwaye yahlanjululwa kwi-Agkistrodon acutus venom, Ubunzima babo be-molecular 39300 kunye ne-26600, ngokulandelanayo.Uvavanyo lwe-vivo lubonise ukuba zombini i-thrombin-efana ne-fibrinolytic enzymes evela kwi-Agkistrodon acutus venom inokwandisa kakhulu ixesha lokuhlangana kwegazi, ixesha leprothrombin elisebenzayo, ixesha le-thrombin kunye nexesha le-prothrombin, kunye nokunciphisa umxholo we-fibrinogen, kodwa indima ye-thrombin- njengee-enzymes zomelele, ngelixa i-fibrinolytic enzymes ibonisa kuphela impembelelo ye-anticoagulant kwiidosi ezinkulu, Isiphelo: I-enzyme efana ne-Thrombin kunye ne-fibrinolytic enzyme evela kwi-Agkistrodon acutus venom ineempembelelo kwinkqubo yokudibanisa igazi kwizilwanyana, kwaye indibaniselwano yezi zibini zinempembelelo ecacileyo ye-anticoagulant.
Ixesha lokuposa: Jan-19-2023