Ityhefu yenyoka inamalungu amaninzi e-bioactive, ngakumbi aquka iprotease kunye ne-polypeptide
Ibalelwa malunga ne-90% ~ 95% yobunzima obomileyo betyhefu yenyoka [l
Ngophuhliso oluqhubekayo lwetekhnoloji, uninzi lweprotheyini yebhayoloji izithako ezisebenzayo kwityhefu yenyoka ngokuthe ngcembe
Iye yahlukaniswa yaza yahlanjululwa, yaye abantu baye bayenza loo nto
Yenza uphando olunzulu ngayo ngeenjongo zokusebenzisa izithako ezisebenzayo zonyango kwityhefu yenyoka ebantwini.
Kunyango lwezifo ezifanayo.Okwangoku, izithako ezisebenzayo zamachiza asebenzayo aqulethwe kwityhefu yenyoka
Uphando lweziyobisi kunye nesicelo seklinikhi esiqhutywayo sigxile kakhulu kwi-antithrombotic, hemostatic kunye ne-hypoglycemic
Uxinzelelo, i-anti-cancer kunye ne-painkillers.
L Amachiza eAntithrombotic
Iprotease yesihlungu senyoka ene-anti-thrombotic kunye ne-thrombolytic iziphumo ikakhulu ibandakanya i-Ancelor
I-Enzyme (i-hoe crod), i-batmxobin, i-defibrase (i-de coerase) kunye ne-Agkistrodon acutus
I-enzyme (autobin).Ezithathu zokuqala zezesnaI [e venom
I-Thmmbin njengee-enzynles, s Ⅷ.E), i-sVTLE yi-serine protease, iyafana ne
Ine-arginine esterase kunye nomsebenzi we-amidase - 1. I-Snake venom thrombin-like enzyme
Isebenza kwi-fibrinogen ukukhulula i-fibrinogen A okanye i-B, ngaloo ndlela
Iyakwazi ukudibanisa i-polymerization yentloko kunye nomsila we-fibrin monomer, kuba ibonisa i-thrombin.
Umsebenzi kwaye ubizwa ngokuba yi-thrombin-like.Kwangaxeshanye, ubuthi benyoka i-thrombin-efana ne-enzyme ayinakufunyanwa ebantwini
Yenza i-coagulation factor x Ⅲ in vivo, kunye nefibrin monoma eveliswe yihydrolysis yayo inga
Intloko kunye nomsila polymerization, kodwa ayikwazi ukuvelisa icala chain cross-linking, ekulula ukuba yonakaliswe inkqubo yendalo reticuloendothelial
Inqanaba le-plasma fibrinogen liyancitshiswa ngenxa ye-phagocytosis okanye ukuthotywa kwenkqubo ye-fibrinolytic
Ikwimeko ye-benign fibrinolytic, ngoko ke ibonisa i-anticoagulation kunye nokudakumba emzimbeni
Fibrillation H1.I-Agkistrodon acutus enzyme yeye-enzyme ye-fibrinolytic, eyi-fibrinolytic
Isifinyezo se-enzyme [Erin (ogen) ol "icenzyme, FLE] inokohlulwa ibe yityathanga elinye
I-Zinc metalloproteinase kunye nekhonkco elinye okanye i-double-chain serine protease, ikakhulu iqanda lentsimbi ye-zinc
I-enzyme emhlophe.I-enzyme ye-snake venom fibrinolytic ayifuni kusebenze i-activator, kwaye inokusika ngokuthe ngqo imicu.
Iprotein (iprotogen) ivelisa i-hemofibrin, ngoko ayisayi kubangela ukudityaniswa “J.
Ukusuka kwityhefu yeAgkistrodon halys (umzekelo, sek, № r [md ∞ ukuya, inqanawa) eMalaysia
I-ankylose eyedwa yayiyeyokuqala ukusetyenziswa kunyango lwezonyango lwezifo ze-thrombotic
Ichiza le-SVTLE.6 J. Emva kophuhliso lwe-Ancelose, yakha yaphononongwa ngamazwe amaninzi
Abaphandi bakholelwa ukuba i-sV'11E lelona chiza lithembisayo kunyango lwezifo ze-thrombotic,
Ukongeza ekusetyenzisweni kunyango lwe-peripheral thrombosis, inokusetyenziselwa unyango lwe-thrombosis enzulu ye-venous kunye ne-thrombosis ephakathi.
I-pulse thrombosis nayo inefuthe lokunyanga “J.Ngeminyaka yee-1990, amazwe amaninzi kunye nemimandla
U-Qu Du unomdla kakhulu kunyango lwe-acute cerebral ischemia kunye ne-stroke nge-aclase, kwaye
Iprojekthi yenkxaso-mali: iProjekthi yezoNyango lwezoNyango kunye neTekhnoloji yoKulinywa koLutsha (13QNP068);Umkhosi wonke “12
5 “iprojekthi yophando lwezonyango ngokubanzi (cwslJ280);Ingingqi yaseChengdu yasemkhosini "iSicwangciso seminyaka emihlanu ye-12" Uphando lwezoNyango
Iiprojekthi eziphambili (B12026);Iprojekthi yophando lwezonyango ngokubanzi kwiNgingqi yoMkhosi yaseChengdu ngexesha le-12 yeSicwangciso seminyaka emihlanu
(C12062)
Iyunithi yombhali: 650032 Kunming, iZiko loMmandla weNgingqi yaseChengdu yoLawulo lweSifo kunye noThintelo (Zhang Zhixiao,
Hu Tingsong, Cui Qinghua, Zheng Ying, Fan Quanshui);IiPathogens, iSikolo soNyango oluSiseko, iKholeji yezoNyango yaseYoujiang yeSizwe
I-Biology kunye ne-Immunology Ofisi yokuFundisa kunye noPhando (Xie Zhenfeng)
Umbhali ohambelanayo: Fan Quanshui, i-imeyile: fqsl68@126.com
Kuye kwenziwa izifundo ezininzi zeklinikhi ezincinci.Isalathisi sovavanyo lokusetyenziswa kweziyobisi
Ukongeza, i-Ancelose ingasetyenziselwa unyango lweklinikhi yezigulane ezine-acute ischemic stroke kwinqanaba lokuqala
Ibonisa umphumo omhle wokunyanga.Emva koko, nge-randomized enkulu-imfama kabini, iperi ye-placebo
Ngokutsho kovavanyo lweklinikhi, yena, njl. Kwiimeko ezingama-2613 ze-acute
Iziphumo zonyango lweziyobisi zezigulane ezine-ischemic stroke ngokwesondo ziqinisekisile ukuba izigulane kwiqela le-cloroxobin
Izinga lokusinda liye landa kakhulu, kodwa ingozi yokopha kwi-intracranial nayo yandiswa.Emveni kwalonto
Ulingo lwezonyango lwezigulane ze-1222 ezine-acute ischemic stroke ziqinisekisile ukuba emva kweeyure ze-3
I-Ancelose ayikhuthazwa kunyango.1…. I-United States neKhanada yapapashwa ngo-2009
Imivimbo ye-500 ebandakanya amazwe angama-12 kunye nemimandla equka iCanada ne-Australia
ubethakala kwi
Ixesha lokuposa: Feb-26-2023