Ukulungiswa kwe-Agkistrodon acutus venom

Ityhefu ye Agkistrodon acutus (ekwaziwa njenge Agkistrodon acutus) itsalwa ngokucinezela impumlo kunye nokucudisa, kwaye idityaniswe ne 5O yamayeza esintu aseTshayina afana newolfberry.Yenziwe ngokufunxwa, ukusetyenzwa kunye nokucoca iinkozo eBaijiu.Idityanisiwe kwi

I-Agkistrodon acutus venom inemisebenzi yokuchasana nokudinwa, ukulwa nokuguga, ukuqinisa ukhuseleko, ukukhuthaza ukutya, ukuphucula umnqweno wesini, kwaye inefuthe elicacileyo lokunyanga kunyango lwezifo zesikhumba kunye ne-psoriasis (psoriasis) . amacala omabini entloko nomhlathi wenyoka

Ukukhutshwa kwedlala letyhefu kumhlophe qhwa okanye kumhlophe kancinci okuvuselela ukuphuma kwamazinyo etyhefu kumacala omabini ombhobho.

Ulwelo lwe-viscous olutyheli lolunye lweyona tyhefu inamandla ejikeleza igazi kwiityhefu zezilwanyana.ingcebiso

Ityhefu entsha ye-Agkistrodon halys iyalotywa kancinane, kwaye iinxalenye zayo eziyityhefu zintsonkothile, ngakumbi ukujikeleza kwegazi.

Inetyhefu [1], equlathe ukuntsonkotha kwepolypeptide kunye neeenzymes ezininzi, iphospholipase A Protease

Kwaye i-kallikrein, njl. Ubuhlungu benyoka bunokubangela umonakalo omkhulu kwizicubu zomntu okanye zezilwanyana

Ukukhubazeka nokufa.Nangona kunjalo, iimveliso ezinobuhlungu benyoka zinokusetyenziswa njengokutya okunempilo ekulweni nokudinwa

Ukwaneliseka kukudinwa, ukuchasa ukuguga, ukomeleza amandla omzimba, ukukhuthaza umdla wokutya, ukwandisa umnqweno wesini, njl.

isiphumo.Emva kokuba ityhefu yenyoka ifakwe kwi-ethanol, ayinalo ivumba lentlanzi, iprotheni kunye nentambo ye-cytotoxic.

Ukulahleka kwe-toxin yegazi akuyi kukhokelela ekudibaneni kwezicubu, i-edema kunye ne-necrosis, ngelixa i-phospholipase A.

Iprotease kunye ne-kinin azibangeli ukuba umzimba ukhulule i-kinin histamine kunye nombala we-5-hydroxy

I-amines kunye nezinye izinto.Ngenxa yesi sizathu, umbhali kunye neqela lophando basebenzisa ubuthi be-Agkistrodon acutus njengento ephambili

I-Qi kunye namanye amayeza e-herbal aseTshayina asetyenziswa njengezinto ezincedisayo [2], ezicutshungulwa kwaye ziphuhliswe ngomyalelo wesayensi wengqolowa Baijiu.

I-Agkistrodon acutus venom (imveliso entsha) enokhathalelo lwempilo kunye nesiphumo sonyango kunye nokusetyenziswa okufanelekileyo

Ukuhlangabezana neemfuno zemarike kunye neemfuno zabantu zokhathalelo lwempilo kunye nonyango lwezifo.

1 Izinto kunye neendlela

1.1 Isixhobo Ubuhlungu be-Agkistrodon acutus (umgubo omtsha kunye ne-lyophilized) buya kuba mtsha kwaye bukhali kwiiyure ezili-18.

Ubuthi obuphezulu benyoka ye-Agkistrodon halys venom kunye ne-lyophilized powder ayinagazi kunye nokungcola.Iyeza elitsha lezityalo zaseTshayina

I-Lycium barbarum, entsha, ngaphandle kokubola kunye nokuwohloka, njl.

1.2 Izixhobo kunye nezixhobo KFL-1035 oral liquid ukutywina umatshini

Machinery Co., Ltd.).

1.3 Indlela (1) Nyibilikisa ubuthi obutsha be-Agkistrodon acutus (umgubo owomileyo owenziwe ngumkhenkce we-Agkistrodon acutus) emanzini angenanto.

50 (5O.) iinkozo iBaijiu yafakwa emanzini yaza yatywinwa kangangeentsuku ezingama-30 ukuze ihlanjululwe.

(2) Hlamba imifuno entsha yaseTshayina efana ne-wolfberry, yomise amathontsi amanzi, kwaye wongeze i-5O.Iinkozo zeBajiu

Gxininisa kwi-1/lO yoxinaniso lwecandelo leentsuku ze-3O (vuselela kanye ngeentsuku ezili-10, ungatywini ngaphambi kokuxuba, kwaye uvuselele

Emva kokutywinwa).(3) I-Baijiu icocwe ngokufunxa ubuthi be-Agkistrodon acutus ngayo

I-Baijiu emanziswe yaza yacocwa ngamayeza esintu aseTshayina ixutywa ngokulinganayo, ibhotile, igqunywe, ifakwe iradiation kunye nokucoca, kwaye ivavanyiwe ukuba ifanelekile.

(Umgangatho wemveliso: ① Isalathiso soluvo: I-Agkistrodon acutus venom imdaka ngokukhanyayo kunye nesiqingatha esibomvu

Ulwelo olucacileyo olucacileyo, ubisi oluxubeneyo olufana neprotein emdaka kumaleko asezantsi lunokubonwa ngamehlo,

Vuthulula kakuhle ngaphandle kwentsalela ye-caking, incasa enevumba elimnandi, ivumba elimnandi, ivumba elingaqhelekanga, incasa emuncu kunye nokungunda

Ngcamla.② Izalathisi zenyama kunye neekhemikhali [: i-ethanol degree 45 ~ 48.Inkokeli (ibalwa nguPb)

I-0.10g / kg, i-arsenic (ibalwa njenge-As) ≤ 0.5mg / kg, ubhedu (ibalwe njengeCu) ≤ 1.0

Mg/kg, methanol ≤ O.04g/lO0ml, fusel oil ≤ O.1/100ml, cyanide

IManganese ayibonwa.③ Isalathisi seMicrobiological: inani elipheleleyo lebhaktheriya<1000/g, iqela le-coliform

≤ Iziqwenga ze-30 / lOOg, iibhaktheriya ze-pathogenic azibonakali), zipakishwe njenge