Iziko leNyoka yeNyoka kunye nokulunywa yiNyoka, kwiKholeji yoNyango yaseMazantsi eAnhui
Iziko loPhando kwisiXeko saseWuhu, kwiPhondo laseAnhui
Uphando ngobuhlungu benyoka kunye nenxeba lenyoka laseSouthern Anhui Medical College lwaqala phakathi koo-1970, kwaye wayelilungu leQela le-Anhui lePhondo leNyoka loNyango lweNdibaniselwano ngelo xesha.Lelinye lamaziko okuqala ukwenza uphando olusisiseko kunye nolusetyenziswayo ngobuthi benyoka eTshayina.
Igama lesiTshayina
Iziko leNyoka yeNyoka kunye nokulunywa yiNyoka, kwiKholeji yoNyango yaseMazantsi eAnhui
indawo
IPhondo laseAnhui
uhlobo
Phumelela esikolweni
into
Ityhefu Yenyoka kunye Nenxeba Lenyoka
Iziphumo zophando zeZiko
Intshayelelo yeZiko
Uphando ngobuhlungu benyoka kunye nenxeba lenyoka laseSouthern Anhui Medical College lwaqala phakathi koo-1970, kwaye wayelilungu leQela le-Anhui lePhondo leNyoka loNyango lweNdibaniselwano ngelo xesha.Ngo-1984, phantsi kolawulo lukaNjingalwazi Wen Shangwu, umlawuli wesebe lokufundisa kunye nophando lwabafundi bokuqala abagulayo, i-Ofisi yoPhando lweNyoka kunye neNyoka yeNyoka yasekwa, enye yeziko lokuqala ukwenza uphando olusisiseko kunye nolusetyenziswayo. kwityhefu yenyoka eTshayina.Kwi-2007, i-Ofisi yoPhando lweNyoka kunye neNyoka yeNyoka yabizwa ngokuba yiNkomfa yoPhando lweNyoka yeNyoka yeKholeji yezoNyango yaseSouth Anhui, kwaye umlawuli wangoku nguNjingalwazi uZhang Genbao.Kwiminyaka eyi-30 edlulileyo, impumelelo yophando olusisiseko kunye nesetyenzisiweyo kwi-toxins yenyoka enobuhlungu kumzantsi we-Anhui yenze igalelo elibalulekileyo ekuthinteleni nasekulawuleni ukulimala kweenyoka kunye nokusetyenziswa kwemithombo yetyhefu yenyoka e-China;Ezona nyoka zinobuhlungu kumazantsi eAnhui yiAgkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head kunye neBungarus multicinctus, ngakumbi iAgkistrodon acutus, echaphazela kakhulu impilo nobomi babantu abasezintabeni.Uphononongo lubonise ukuba ezi nyoka ezinobuhlungu ikakhulu zivelisa i-toxins ye-blood circulation kunye ne-neurotoxins, enokubangela ukuba izigulane zihlupheke kwi-disseminated intravascular coagulation (DIC) kunye nokopha kwesibini, ukothuka, ukungaphumeleli kwamalungu amaninzi kunye nezinye iziphumo ezimbi;Ngophononongo olucwangcisiweyo malunga netyhefu yegazi ye-Agkistrodon acutus (Agkistrodon acutus) kumazantsi e-Anhui, kwafunyaniswa ukuba i-DIC eyayanyaniswa nokulunywa yinyoka yayiyenye yeempawu zendalo zetyhefu yokuqala, kwaye yayahlukile kwi-DIC echazwe ngokwemveli. iimbono.Ngoko ke, ingcamango ye-"DIC efana" ye-syndrome kwizigulane ezilunywe yi-Agkistrodon acutus yaqala ukucetyiswa e-China (1988), Kwaye kwaqatshelwa ukuba i-thrombin efana ne-enzyme (TLE) kunye ne-fibrinolytic enzyme (FE) equlethwe kwityhefu ye-Agkistrodon acutus oyena nobangela uphambili wale “DIC like” (1992).Oku kubaluleke kakhulu ukucacisa iimpawu zokutshintsha kwegazi kwizigulane ezine-Agkistrodon acutus, kwaye zibonelela ngesiseko sethiyori sokusetyenziswa kwe-antivenin ethile ukunyanga le ngxaki.Kuphononongo lwendlela yokopha okubangelwa yi-Agkistrodon acutus venom, kwafunyaniswa ukuba le tyhefu yenyoka ibenempembelelo kumacandelo amathathu enkqubo ye-hemostatic (izinto ezidityanisiweyo, iiplatelets kunye neendonga zemithambo yegazi), apho ihaemotoxin ngqo. kuchaphazele ukugqobhoza kweecapillaries.Kwangaxeshanye, kwafunyaniswa ukuba ukopha okunzulu okubangelwa yityhefu yetyhefu ye-Agkistrodon acutus kunye nobunzima bokudumba kwamalungu awonzakeleyo ukuba athobe kwakunxulumene nokuvaleleka kwe-lymphatic supplement of coagulation factor in the thoracic duct kunye ne-lymphatic flow rate.Ezi ziphumo zophando ezisisiseko nezisetyenziswayo ziye zadlala indima ephambili kwintsebenziswano yexesha elide kunye neQimen Snakebite Research Institute ekuqulunqeni ngokufanelekileyo isicwangciso sonyango lokulunywa yinyoka enobuhlungu kunye nokuqinisekisa ukhuseleko lwezigulane ezilunywa yinyoka, kwaye iphumelele imiphumo ebalulekileyo yentlalontle.Iziphumo zophando ziye zaphumelela ngokulandelelana iMbasa yeMpumelelo yeNzululwazi neTekhnoloji yePhondo lase-Anhui, iMbasa yeNkqubela yeNzululwazi neTekhnoloji yePhondo lase-Anhui (1993), kunye nenqanaba (A) leMbasa yokuPhumelela kweNzululwazi nobuChwepheshe kwiSebe lezeMpilo (1991);Ngo-1989, isebenzisana ne-Wuhan Institute of Biological Products ukuphuhlisa i-antibody ye-monoclonal ngokuchasene ne-thrombin efana ne-enzyme ye-Agkistrodon acutus venom, eyayiyimpumelelo yokuqala e-China;Kwi-1996, yavelisa ngokudibeneyo kwaye yaphuhlisa iimveliso ze-thrombin (YWYZZ 1996 No. 118004, i-patent CN1141951A) kunye neZiko leeMveliso ze-Biological kunye neZiyobisi ze-Jinan Military Region.
iziphumo zophando
Kwiminyaka yakutshanje, ilabhoratri yahlula kwaye yacoca iintlobo ngeentlobo zezinto eziphilayo ukusuka kwityhefu ekrwada ye-Agkistrodon acutus, i-Agkistrodon halys kunye ne-Cobra kumazantsi e-Anhui, ezifana ne-anti hypercoagulable state enzymes, i-protein C activators (PCA).Uphononongo lovavanyo luqinisekisile ukuba ezi zithako zisebenzayo zinokuchaphazela inkqubo yokuqina, zichaphazela ukunamathela kweplatelet, ukudityaniswa kunye nokukhusela umsebenzi weeseli ze-vascular endothelial, kwaye zinokusebenza okuphezulu kunye netyhefu ephantsi ye-anticoagulation kunye neziphumo zethrombolytic, Oku kubaluleke kakhulu kuthintelo kunye nonyango. izifo ze-thrombotic kunye nokuphuculwa kwe-hypercoagulability yegazi;Ngelo xesha, kwafunyaniswa ukuba i-PCA evela kwinyoka yenyoka inefuthe elithile lokubulala iiseli ze-leukemia ze-K562 kunye nokuvimbela i-metastasis yeeseli zomhlaza.Ithemba layo lesicelo seklinikhi libanzi kakhulu.Iofisi yophando iqhube ngokulandelelana kwaye yagqiba iiprojekthi ezininzi zophando, ezifana "neMechanism ye-DIC ebangelwa yi-Agkistrodon acutus venom", "Uphando malunga nendlela yokopha okubangelwa yi-Agkistrodon acutus venom kwizilwanyana", "Ukuxilongwa kwenyoka kunye nokuxilongwa ngokuhlukileyo usapho lwenyoka ngendlela yokubhala i-enzyme”, exhaswa ngemali yiNational Natural Science Foundation, iSebe lezeMpilo, iSebe lezeMpilo kunye neSebe leMfundo lePhondo laseAnhui;Okwangoku, iiprojekthi eziphantsi kophuhliso ziquka: "Uphando kwi-Hemorrhagic Anticoagulant Protein ye-Agkistrodon acutus", "Uphando kwi-Molecular Mechanism ye-Effect ye-PCA esuka kwi-Agkistrodon halys Pallas Venom kwi-Vascular Endothelial Function", "Uphando lwe-Biology ye-Molecular I-PCA esuka kwi-Agkistrodon acutus Venom ngokuchasene neeSeli zeTumor”, kunye noKwahlula kunye nokuCocwa kweeNgxelo ze-Nerve Analgesic kwi-Cobra Venom.
Iziko lophando lwetyhefu yenyoka yeKholeji yezoNyango yaseSouth Anhui ineemeko ezilungileyo ezisisiseko, izixhobo zophando ezipheleleyo, isakhiwo seqela lophando esinengqiqo, kunye nenkqubela phambili eqhubekayo kwiindlela zophando kunye neendlela zobugcisa.Kulindeleke ukuba wenze impumelelo emitsha kuphando lwezenzululwazi, uqeqesho lwabasebenzi, njl njl. Imithombo yetyhefu yenyoka esezantsi kwe-Anhui inobutyebi kwaye ixabiseke kakhulu.Ikhemesti yetyhefu yenyoka lichiza elinamalungelo epropathi enomgangatho ophezulu wokuqonda eTshayina.Iziphumo zophando ngesiseko kunye nokusetyenziswa kwetyhefu yenyoka kunye namacandelo ayo abaluleke kakhulu ekuphuhlisweni kwemithombo ye-snake ecebileyo kwi-Anhui esezantsi kunye nesicelo seklinikhi.
Ixesha lokuposa: Nov-11-2022