Ngenxa yokuba amayeza emveli aseTshayina akholelwa ukuba yinxalenye "yempahla yenyama kunye negazi", ixabiswa kakhulu.Iyeza lemveli laseTshayina kwizilwanyana ezinetyhefu lidlala indima ebalulekileyo kuphando kunye nokusetyenziswa kwamayeza esintu.Nangona kunjalo, okwangoku, kukho uphando oluncinci kumacandelo athile asebenzayo kunye nendlela yokusebenza yezilwanyana eziyityhefu zesiNtu zaseTshayina eTshayina.I-bottleneck ephambili kukuba amacandelo ayo anzima, kunzima ukuhlukana kunye nokuhlanjululwa, kwaye kunzima ukuchonga isakhiwo sayo.Lai Ren, Xiong Yuliang, Zhang Yun, Xiao Changhua, Wang Wanyu kunye namanye amalungu eqela lophando Kunming Institute of Zoology, Chinese Academy of Sciences kudala bafunda isiseko eziphathekayo kunye nendlela yokusebenza kakuhle amayeza emveli Chinese izilwanyana eziyityhefu, waseka ithala leencwadi elisebenzayo lemolekyuli esebenzayo, waphuhlisa amachiza amaninzi, kwaye ngokuthe ngcembe waseka "inkqubo yetekhnoloji ekujoliswe kuyo yamacandelo asebenzayo amayeza emveli aseTshayina kwizilwanyana ezinetyhefu esekelwe kubuchule bokusinda bebhayoloji".Iimpawu zale nkqubo yetekhnoloji zezi: 1) ukusungulwa kwethiyori: ukuthatha isicwangciso sokusinda sezilwanyana ezinetyhefu njengesikhokelo sethiyori ukuphonononga amacandelo asebenzayo;2) Ubuchwephesha obutsha bobugcisa: iiproteomics ezidityaniswe ne-pharmacology zisetyenziselwa ukulandelela ukuhlukana kunye nokuhlanjululwa kwamacandelo asebenzayo;I-3) I-innovation ehlanganisiweyo: yenza inkqubo yeteknoloji yezemigodi ekujoliswe kuyo kumacandelo asebenzayo ezilwanyana ezinobuthi kunye namayeza emveli aseTshayina asekelwe kwizicwangciso zokusinda zebhayoloji, ukuchonga isiseko sezinto zezicwangciso zabo zokuphila, kunye nokuveza isiseko sezinto kunye nendlela yokusebenza yaloo mayeza emveli aseTshayina.Ngale nkqubo yobugcisa, bachonge isiqabu kwiintlungu, i-hemostasis, i-antithrombotic, i-hypotensive, i-anti-cancer, i-anti-bacterial, i-anti-oxidation, i-anti rheumatic arthritis Ulawulo lwe-Immune kunye nezinye iimolekyuli ezifanelekileyo ezisebenzayo zibonisa isiseko sezinto ezi mayeza ukuze zisebenzise ukusebenza kwazo. , kunye nokungqina ngokuthe ngqo ukusebenza kolu hlobo lweyeza zesiNtu zaseTshayina kwinqanaba le-molecular;Kwangaxeshanye, iphinde ichonge ezinye izinto ezibangela ukwaliwa, ukopha kunye nezinye iziphumo ebezingalindelekanga ezinxulumeneyo, ukunika isikhokelo sokusetyenziswa ngokukhuselekileyo kwezi zixhobo zonyango.Olu chungechunge lomsebenzi lubeke isiseko esiluqilima sokuphuculwa kwamayeza emveli aseTshayina kunye nophando kunye nophuhliso lwamachiza olutsha olu hlobo lwamachiza.Ifumene amalungelo awodwa omenzi wechiza angama-30 kunye ne-1 imodeli yelungelo elilodwa lomenzi wechiza, evelise ixabiso lezenzululwazi, lentlalontle kunye nezoqoqosho, elibonakaliswa ikakhulu: 1) ekuvezeni izithako ezisebenzayo zala mayeza emveli aseTshayina kwinqanaba lemolekyuli.Baye bachonga ngaphezu kwe-800 iamolekyu ezisebenzayo ezivela kulezi zixhobo zonyango (kubandakanya i-peptides ye-antimicrobial, i-bradykinin, i-tachykinin, i-antithrombotic peptides, i-protease inhibitors, i-proteases, i-bombesin, i-antioxidant peptides, i-immunosuppressants, i-phospholipase, i-melittin, i-neurodestoxic kunye nokulungiswa kwesikhumba). kunye nokuhlalutya izakhiwo zabo, iithagethi zentshukumo kunye neendlela;2) Ukuchongwa kwamaqela asebenzayo eemolekyuli kubonelela ngesiseko senzululwazi sokuqulunqwa, ukusetyenzwa kunye nokusetyenziswa kwale migangatho kumayeza emveli aseTshayina;3) Ukuchonga izinto ezineziphumo ebezingalindelekanga eziyityhefu ezifana allergens kula mayeza Chinese herbal inika indlela yokwahlula kunye nokususa ityhefu kunye neziphumo ebezingalindelekanga kule amayeza esintu yaseTshayina, kwaye ibonelela ngeembono uxilongo kunye nokuthintela ityhefu enjalo Chinese herbal;4) Ezinye iimolekyuli ezisebenzayo ezivela kwityhefu yezilwanyana ziye zaphuhliswa zaba ngamachiza ekliniki okanye ziphantsi kophuhliso, kubandakanywa icobra polypeptide neurotoxin polypeptide, agkistrodon acutus venom thrombin, vespid polypeptide, gadfly anti laren, owazalwa ngo-1972, umphandi kunye nomphathi wobugqirha weKunming Institute of I-Zoology, i-Academy yaseTshayina yeSayensi, iphumelele iNgxowa-mali yeSizwe yeeNzululwazi eziBalulekileyo, kwaye yazisa iitalente kwi-"Hundred Talent Program" ye-Chinese Academy of Sciences kwi-2004. Ukususela ngoJanuwari 2014, amaphepha e-125 SCI ashicilelwe njengowokuqala okanye umbhali ohambelanayo, njengeProc Natl Acad Sci, i-Mol Cell Proteomics, i-Hypertension, njl.Umenywe ukuba asebenze njengosekela-mhleli we-J Venom Res;Senze isicelo samalungelo awodwa omenzi wechiza angaphezu kwama-70.Lenze iinkqubo ezingundoqo zeSiseko seSizwe seNzululwazi yezeNdalo yaseTshayina, iNgxowa-mali yeSizwe yeNzululwazi yeeNzululwazi eziBalulekileyo eziBalulekileyo, iNkqubo ye-973 yeSebe lezeNzululwazi kunye neTekhnoloji, inkqubo enkulu entsha yokufunyanwa kweziyobisi, kunye neenkqubo zolwalathiso lweZiko lemfundo yaseTshayina. yeNzululwazi.Iphumelele ngokulandelelana iMbasa yeSizwe yeTekhnoloji yokuNgenisa (i-2013, ibekwe kwindawo yokuqala), iSayensi yoLutsha yaseTshayina neMbasa yeTekhnoloji (2011), iMbasa yeSayensi yoBomi yeTan Jiazhen (2010) kunye namanye amawonga.I-Thrombotic polypeptide, i-centipede polypeptide, njl.I-5) Siye saqulunqa iindlela zonyango lwetyhefu yenyoka kunye netyhefu yenyosi, ukubonelela ngeendlela zobugcisa ezisebenzayo zokunyanga izigulane ezinobuthi benyoka kunye netyhefu yenyosi.I-Kunming Institute of Zoology, i-Chinese Academy of Sciences iphumelele iziphumo eziphawulekayo zophando kwiinkalo ezifanelekileyo: kwiminyaka yakutshanje, ipapashe amaphepha e-SCI angaphezu kwama-200, kwaye yaphumelela amabhaso okuqala angama-4 kwiphondo kunye nabaphathiswa kunye namabhaso e-6 yesibini.Ngo-2013, i-Kunming Institute of Zoology, i-Chinese Academy of Sciences iphumelele ibhaso lesibini le-National Technological Invention Award yeprojekthi ye-"Directional Mining Technology System for Functional Components of Toxic Animal Traditional Chinese Medicine esekelwe kwi-Biological Survival Strategy".
Ixesha lokuposa: Dec-09-2022